March 17, 2022: Safety Bulletin - Heightened Risk of Methotrexate Toxicity in End-Stage Renal Disease
Chronic kidney disease resulting from a decline in renal function affects approximately 3% of Canadians. End-stage renal disease, typically leading to the need for dialysis or kidney transplant, may develop as a patient's renal function worsens. Many medications should be avoided by or prescribed at a lower dose for patients with impaired renal function to prevent toxicity. Prescribing can be further complicated by polypharmacy and comorbid illnesses, such as liver dysfunction. This bulletin describes findings from 2 harmful incidents involving patients for whom methotrexate was prescribed while they were receiving dialysis. Listen to the Synopsis ... | Read more ...
